No one is ever really 100% sure about anything. You can always conceive of some way for what you expect to happen to turn out to be completely wrong.
Sometimes scientists can sound like they have no idea what they are talking about. Will the latest batch of high-energy particle experiments destroy the Earth?
Probably not. Could a nuclear power plant start a chain reaction that ignites the atmosphere, destroying all life?
Unlikely. Are you acknowledging the possibility that you are completely wrong, and that scientists may be bringing about the end of all humanity? That is correct.
You see, we all deal with uncertainty in our lives, but it tends to make us uncomfortable. So we make assumptions, use them to fill in the gaps, and give ourselves a sense that we know what to expect when we head out into the world. Anything less would leave us feeling unprepared. But our certainty stems from inductive logic, not deductive. We never really know what will happen under any circumstance, no matter how may times we've seen the same thing happen again and again. As such, any truly honest prediction will include some level of uncertainty.
An honest scientist is rarely certain: this is the key to discovery. While a scientist may be in the business of controlled experiments, cataloguing of observations, and in the development of applications to industry, we would be very limited if the great pioneers of knowledge simply stuck to what was already known. Every great discovery was at some point unexpected, and time and time again we have learned that nature doesn't give a damn about what we are "certain" of.
So when a scientist tells a news reporter that we may be on the verge of blowing ourselves up in an experiment of unprecedented size and power, it is not to say that the scientist is incompetent, pessimistic, or unfit to discuss matters in which he* is clearly misinformed. It is rather that he has forgotten how uneasy the average person is with uncertainty, and that it would be better if certain assumptions were made for a moment, lest people get the idea that scientists are all a bunch of madmen. One can never be too careful when playing a game of telephone with a media based upon sensationalism.
Or perhaps the scientist is right. Perhaps the desire for people to feel certain is based on an unfounded fear, and that acknowledging uncertainty in all things would lend itself to no more uncertainty than is already present in the world. To be knowledgeable and yet still uncertain is to see the world as it is. All progress is made through questioning and change, and any time we feel like we have all of the important answers in our possession serves only to keep us from developing further. In a time when human society is developing rapidly, an open mind is absolutely essential. Complete certainty must never be imposed. The key to progress and discovery may be to look out into the world and to simply say "I don't know."
* Arbitrarily masculine pronoun